Purpose Right sided colon cancers can take advantage of complex lymphatic drainage across both the mesocolon and mesogastrium. Previous studies have evaluated rates of malignancy across gastroepiploic lymph nodes but without providing firm evidence for or against the routine dissection of these relatively distant nodal stations. This review aimed to identify the rate of infrapyloric (nodal station No. 206) lymph node metastases in right sided colon cancer and evaluate associated surgical morbidity. Methodology A systematic review of the literature was conducted in line with PRISMA guidelines. A critical appraisal of studies was performed and a narrative summary of the findings presented. Results 15 studies were included. The rate of infrapyloric lymph node metastases ranged from 0.7-22%. The highest rates of infrapyloric lymph node metastases were associated with tumours of the hepatic flexure and more advanced disease. Postoperative complication rate ranged from 1.7%-38.2%. 30-day mortality was reported between 0.5%-5.4%. Conclusion Right sided colon cancers frequently metastasise to infrapyloric lymph nodes. Additional infrapyloric lymph node dissection does not appear to be associated with increased morbidity when compared with complete mesocolic excision alone and should be considered for patients with right sided cancers, particularly those of the hepatic flexure.